Aravive Investor Presentation Deck

GAS6/AXL Signaling: High Affinity Decoy Receptor is the Best Approach for Potent and Selective Inhibition Tyrosine Kinase Inhibitor # kinose Domain Selectivity limited by RTK homology Off-target toxicity Multiple resistance mechanisms Many potential competitors AXL or GAS6 Antibody Requires a mAB affinity that competes with receptor Not achievable for AXL Many potential competitors . W Decoy AXL Receptor Binds more tightly to GAS6 than WT AXL Complete target coverage with no anticipated off-target toxicity First-in-Class with strong IP position WT AXL has pM Affinity: Batiraxcept has fM Affinity and Out Competes Endogenous AXL 7

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