Bionomics Investor Presentation Deck

Harnessing the Power of a Novel Neuromodulatory Mechanism Action of BNC210 depends on Acetylcholine neurotransmission and Allosteric Modulation of a7 nACHR Bionomics FP nAChR = Nicotinic Acetylcholine Receptor NAM = Negative Allosteric Modulator Ca²+ = Calcium ions AChAcetylcholine ACh Ca²+ BNC210 Hippocampus Prefrontal Cortex Basal Forebrain Amygdala NORMAL Ca2+ NORMAL MOOD a7nACh Receptor Ca2+ INFLUX Hippocampus Prefrontat Cortex Basal Forebrain Amygdala ANXIETY & PTSD MOOD DISORDERS + BNC210 Ca2+ INFLUX Ca2+ Ca2+ INFLUX BNC210 RESTORES NORMAL MOOD NAMs have self-limiting activity determined by the cooperative interaction between BNC210 and Acetylcholine binding at the allosteric and orthosteric sites, respectively 6

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