23andMe Investor Presentation Deck

CD200R1 is expressed on tumor-infiltrating from The Cancer Genome Atlas (TCGA) CD200R1 expression (using RNAseq data from TCGA) is correlated with several immune cell markers: CD4, CD8, CD45 (shown), and CD11b CD200R1 is co-expressed with antigens or markers that are expressed on lymphocytes seen in most cancer types Log10 (CPM+0.05) of CD45 2.5- CD200R1 correlation with CD45 (hematopoietic cells)¹ 2.0 1.5- lymphocytes (TILs) 1.0- 0.5 rho = 0.86 KIRC -1.0 -0.5 0.5 1.0 1.5 Log (CPM+0.05) of CD200R1 1. Clear cell renal carcinoma (KIRC) is shown and was chosen because it had high immune infiltration in the TCGA dataset Copyright © 2023 23and Me, Inc. 23andMe 43

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