Investor Presentation

Dermatomyositis (DM) at a Glance D Lenabasum Dermato = skin, Myositis = muscle inflammation Pathogenesis Autoimmune disease with organ inflammation, fibrosis, atrophy and vascular changes Common Symptoms Proximal weakness, rash, pain, itch, shortness of breath Current standard of care Immunosuppressives with significant toxicity 25 X * Images (top) Provided by Myositis Support and Understanding; images (bottom) republished with permission of John Wiley and Sons, from Cutaneous Ulceration in Dermatomyositis: Association With Anti-Melanoma Differentiation-Associated Gene 5 Antibodies and Interstitial Lung Disease, Narang, Neera S. et al, 67(5), 2015; permission conveyed through Copyright Clearance Center, Inc.

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