Investor Presentation

22ND CENTURY'S HOPS VALUE PROPOSITION 22nd Century is leveraging its experience with tobacco and hemp/cannabis, a close hop relative, to accelerate the development of proprietary specialty hop varieties or valuable traits. 1 Introduce new agronomic traits to improve disease/pest resistance and plant architecture to increase crop yields in leading hop strains that are already well-accepted by the brewing industry 2 Increase hops content of hops active molecules that drive the beer industry, such as alpha and beta acids, plus new compounds like terpenoids and flavonoids not generally associated with hops to produce new, disruptive, unique, and proprietary aromatic hop flavor profiles 3 Increase hops content of active molecules with health and wellness applications as extracts/distillates in functional foods and beverages, nutraceuticals, and pharmaceuticals (Xanthohumol and 8-prenylnaringenin) Hops Growers PREMIUM QUALITY HOPS Hopsteiner SINCE 1845 YAKIMA VALLEY HOPS Industry Leadership HOP ABInBev RESEARCH COUNCIL DOL Haus des HOPFENS HAAS Consumer Goods and Nutraceutical Companies ★ Heineken P&G THORNEⓇ OP HEAD 1. HOP FARMS FARMS British Hop Association indena 22ND CENTURY GROUP Barth Haas HOPS DIRECT SWANSON USA HOPS Nature's way 18

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