Corporate Presentation
Obesity
Dapiglutide
People with obesity have increased low-grade
inflammation, which drives several related comorbidities
Excess fat storage can trigger low-grade systemic
inflammation through reduced intestinal barrier integrity1
Obese adipose tissue
Dysbiosis
Obesity-related low-grade
inflammation can result in:
ZEAL&
ZEALAND PHARMA
.
•
Insulin-resistance
Impaired gut hormone secretion
Dysregulation of gut-brain-fat axis
'Leaky gut'
Intestinal
permeability
LPS
CVD as increased
inflammation drives residual
risk in people with CVD²
Liver disease due to abnormal
accumulation of triglycerides in
the liver³
↑ Intestinal inflammation
Neuro-inflammation
due to excess circulating
proinflammatory cytokines
and changes in the integrity
of the blood-brain barrier4
20
20
Sources: 1. Figure adapted from Vetrani et al. Nutrients 2022;14(10):2103, used under the Creative Commons Attribution (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). The figure has been reformatted. The publication
is available at https://doi.org/10.3390/nu14102103; 2. Ridker et al. Lancet 2023;401(10384):1293-1301; 3. Luo & Lin. Immun Inflamm Dis 2021;9(1):59-73; 4. Salas-Venegas et al. Front Integr Neurosci 2022;16:798995.
CVD cardiovascular disease; LPS-lipopolysaccharides.View entire presentation