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Novartis Investor Presentation

New Novartis: Our strategy Our focus > Core Therapeutic Areas Technology platforms Priority geographies Capital allocation / structure Our priorities Conclusion Abbreviations Focused on 5 core Therapeutic Areas... Select examples Cardiovascular Disease areas ■ Heart failure & hypertension ■ Atherosclerosis Commercial assets Entresto* sacubitril/valsartan LEQVIO® Immunology ■ Psoriasis ■ Psoriatic arthritis ◉ Spondylitis/Spondylarthritis ■ Hidradenitis suppurativa ■ CSU Sjögren's / SLE/LN Cosentyx secukinumab ILARIS (canakinumab) 150 mg subcutaneous injection 9 Neuroscience ◉ Multiple sclerosis ◉ Spinal muscular atrophy Neurodegeneration, incl. Huntington's, Parkinson's, ALS Kesimpta (ofatumumab) MAYZENT. (siponimod) tablets GILENYA (fingolimod) Capsules Solid Tumors Breast and Women's cancer ■ Prostate cancer ◉ Lung cancer 1. Core TAs Hematology ■ Non-Hodgkin's lymphoma Non-malignant hematological - Immune thrombocytopenia ■ Acute myeloid leukemia / Myelodysplastic syndrome zolgensma Taimovig (erenumab-acce KISQALI PLUVICTO™ ribociclib Tafinlar + Mekinist (dererle niby PIQRAY* (alpelisib) tablets (trainelinib) Advanced LUTATHERA KYMRIAH (tisagenlecleucel) SCEMBLIX® (asciminib) 20 mg. 40 mg tablets PROMACTA JAKAVI (eltrombopag) ruxolitinib Pipeline assets and opportunities Iptacopan (LNP023) C3G, IgAN Pelacarsen (TQJ230) CVRR-Lp(a) Leqvio CVRR-LDLC Cosentyx Multiple indications Remibrutinib (LOU064) CSU lanalumab (VAY736) Sjögren's, SLE, LN Ligelizumab (QGE031) Food Allergy Remibrutinib (LOU064) MS Zolgensma (AVXS-101 IT) SMA IT Branaplam (LMI070) Huntington's Kisqali Adjuvant HR+/HER2- BC TNO155, JDQ433 NSCLC; Colorectal Cancer; Combos NIS793 1L MPDAC / 1L MCRC Iptacopan (LNP023) PNH, aHUS Sabatolimab (MBG453) MDS, AML lanalumab (VAY736) Multiple indications YTB323 DLBCL TA-x (incl. Ophtha, Resp and other assets) not included in the above list. Pelacarsen is licensed from lonis Pharmaceuticals, Inc. 6 Novartis Investor Presentation | September 22, 2022 & NOVARTIS | Reimagining Medicine
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