Immix Biopharma Investor Presentation Deck
N-GENIUS Platform: EXPAND Technology + COBRA Binder (2/2)
CD3Zy
4-1BB
Overview Of Custom EXPAND Technology + COBRA Binder in NXC-201
1 Proprietary Optimized CD37 -
"CD3Zy"
CD8
Transmembrane
Protein
2
N-GENIUS PLATFORM
Source:. Aherie, N., et al Haematologica. 2022; LaFleur, D. PEGS Boston. 2021
NXC-201
EXPAND Technology + COBRA Binder
CD8
Hinge
Tumor Binding Domain
Proprietary Optimized CD8
Hinge Flexibility
Delivers "Digital" Intracellular Signaling
Eliminates Neurotoxicity, Reduce CRS Duration
Enhances Efficacy In Heavily Pretreated Patients
CD8
Signaling
Protein
"Single amino acid substitutions at key sites can affect CAR-T function over 200-fold range"
3
●●●
IMMİX
S BIOPHARMA
EXPAND Technology + COBRA Binder
Modifications
Proprietary Optimized
COBRA Binder Enhances
Tumor Binding + Ensures
High Expression
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