Equillium Results Presentation Deck

Clinical Responses at 12 & 28 Weeks ORR: 45% equillium 18% 27% 56% Week 12 (n=11) ORR: 83% 17% 33% 33% 17% Week 28/EOS (n=6) ORR: 67% 17% 25% 25% 33% Best response (n=12) Greater ORR achieved by 12 and 28 weeks than is expected with standard of care alone Legend Complete Response: > 50% UPCR reduction and < 0.5 g/g Complete Response: > 50% UPCR reduction and 0.5-0.7 g/g Partial Response: > 50% reduction UPCR No Response: <50% reduction or worsening UPCR Best response shown for all subjects dosed with > 1 dose; UPCR based on spot urine collection Based on interim data from 2 Sep 2022-subject to change. Abbreviations: CR: complete response: EOS: end of study: NR no response: ORR: overall response rate= CR + PR: PR: Partial response; UPCR: urine protein creatinine ratio 26

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