Investor Presentaiton

Forward-looking Statements Statements made in this presentation include forward-looking statements, and those statements are subject to risks and uncertainties, which include, but are not limited to, Safeguard's ability to make good decisions about the monetization of our ownership interests for maximum value, or at all, and the return of value to our shareholders, the ongoing support of our existing ownership interests, the fact that our ownership interests may vary from period to period, challenges to achieving liquidity from our ownership interests, fluctuations in the market prices of any publicly traded ownership interests, competition, our ability to attract and retain qualified employees, market valuations in sectors in which our ownership interests operate, our inability to control our ownership interests, our need to manage our assets to avoid registration under the Investment Company Act of 1940, and risks associated with our ownership interests, including the fact that most of our ownership interests have a limited history and a history of operating losses, face intense competition and may never be profitable, the effect of economic conditions in the business sectors in which Safeguard's ownership interests operate, including the impact of COVID-19, and other uncertainties described in our filings with the SEC. Many of these factors are beyond Safeguard's ability to predict or control. As a result of these and other factors, Safeguard's past financial performance should not be relied on as an indication of future performance. We encourage you to read Safeguard's filings with the SEC, including our Form 10-K, which describe in detail the risks and uncertainties associated with managing our business. Safeguard does not assume any obligation to update any forward-looking statements made in this presentation. G www.safeguard.com SFE © 2021 Safeguard Scientifics, Inc. All rights reserved. LISTED NYSE 2

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