Investor Presentation - First Six Months of 2021

136 Investor presentation First six months of 2021 Novo Nordisk has a sustainable tax approach Novo NordiskⓇ Sustainable tax approach approved by the BoD 1 | Commercially driven Business structures driven by commercial considerations Pay taxes where value is generated Effective tax rate of 20 - 22% for 2021 2 | Responsible No artificial structures or tax havens Transfer pricing principles compliant with OECD guidelines Advanced pricing agreements covering >65% of revenues 3 | Transparent Open about tax practices and maintain cooperative relationships with tax authorities Tax approach published on novonordisk.com • Total tax contribution in 2020 around DKK 26 billion Corporate income taxes by region - three year average in DKK billion Region IP rights¹ Production² Sales³ Corporate income taxes International Operations 8.4 - Denmark 7.2 0.9 - EMEA (excl. Denmark) - Region China - Rest of World North America Operations - The US Total Share of category 1 Intellectual property rights based on sales from where intellectual property rights are located, 2 Production based on production employees in the region, 3 Sales based on the location of the customer. OECD: The Organisation for Economic Co-operation and Development Note: All figures and graphs are average 2018-2020 ㅎㅎ 0.2 0.1 1.5 1.4 9.9

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