First Quarter 2018 Investor Presentation
Investor Presentation
First three months of 2018
Slide 95
Other serious chronic diseases
Serious chronic diseases are often associated
with diabetes and obesity
New therapeutic areas represent patient
populations with high unmet medical needs
CVD
70% of people with diabetes
die from atherosclerotic CVD
40% of people hospitalised for
heart failure have diabetes
Estimated patients
CVD
~420 million
Number of related deaths
~20 million annually
Estimated patients
Diagnosis rate
NASH
80% of people with NASH
are obese and 35% have
diabetes
NASH
~15-40 million 1
CKD
~200 million
~20%2
~20%
CKD
40% of people with diabetes
have diabetic nephropathy and
50% are obese
CVD: Cardiovascular disease; NASH: Non-alcoholic Steatohepatitis; CKD: Chronic kidney disease
Source: Diabetes Care 2005 Jan; 28(1): 164-176
changing
diabetes
1 Internal forecast comprising US, Europe and Japan
2 Diagnosis rate is considered a major uncertainty to the forecast
Source: Abera SF et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes,
1990 to 2015, 2017; Heart Disease and Stroke Statistics, American Heart Association, 2017; Williams
CD et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely
middle-aged population utilizing ultrasound and liver biopsy, 2011; Addressing the global burden of
chronic kidney disease through clinical and translational research, 2014View entire presentation