Investor Presentaiton

Case Studies of Saved Eyes: Neoadjuvant Treatment of UM Patients Initial Cases of Systemic Neoadjuvant Therapy resulting in Prevention of Enucleation Case 1: Eye Saved by Neoadjuvant Treatment +^ UM patient was blind in one eye, developed a large ocular tumor in other eye causing vision loss, and diagnosed with UM Large Ocular Lesion – 16.5 mm Apical Height x 18 mm LBD Tumor Shrinkage observed at each month of treatment with Darovasertib + Crizotinib (~30% at 1 mo and ~80% at 4 mo) Avoided Enucleation and prevented complete blindness Restored > Normal Vision with neoadjuvant treatment and intraocular lens replacement for treatment of cataracts Residual Tumor treated with Plaque Brachytherapy Patient remains on Daro + Crizo Combination Therapy Baseline Scan: 16.5mm Apical Height 4 Month Scan: 3.5 mm Apical Height Regressed Tumor Not Impeding Optic Disc & Macula Large Tumor Impeding Optic Disc & Macula Macula + * Baseline Scan Case 2: Eye Saved by Neoadjuvant Treatment UM patient with large tumor enrolled in NADOM IST study Reduction in Tumor Size of ~24% observed following 4 mo neoadjuvant treatment with darovasertib Tumor Proximity to Optic Disc and Macula - observed increased separation from tumor following treatment for 3 mo Avoided Enucleation and Preserved Vision Residual Tumor treated with Plaque Brachytherapy Tumor Distance of tumor tip to optic disk at baseline 3 Month Scan Tumor Patient remains on Darovasertib as Adjuvant Therapy + Ocular tumor shrinkage based on % reduction in tumor apical height; LBD = Largest Basal Diameter 19 ^ Data and images courtesy of Dr Rod O'Day, LLB (Hons), BSc, MBBS (Hons), FRANZCO, Ocular Oncology Unit Royal Victoria Eye and Ear Hospital, Melbourne Australia. Additional patient care provided by Dr Daniel McKay, MBBS(Hons) FRANZCO FRCPA and Dr John McKenzie, MBBS, FRACS, FRCOphth, FRANZCO * Data and images courtesy of Professor Anthony Joshua, MBBS, PhD, FRACP, Head Department of Medical Oncology, Kinghorn Cancer Centre, St. Vincent's Hospital in Sydney, a principal investigator in the NADOM IST Optic Disc Increased separation of tumor after 3 mo treatment BIOSCIENCES IDEAVA

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