Investor Presentation Full Year 2021

99 Investor presentation Full year 2021 Insulin market size and volume market share in EMEA Insulin market share and market size (DKK billion) Total 48% Long- acting 40% Fast- 56% 12 acting 74% Premix 3 44% Human 3 18 Market growth A Market share Insulin volume: market share 80% 37 -1.2% +0.8% 60% 0.3% +1.5% EMEA 15% 12% 9% 47.6% 40% 6% 0.3% -0.3% 20% -4% +1.9% 0% Nov 2018 -11% -0.6% NN market share 3% 0% -3% Nov 2021 Novo Nordisk Competitors Source: IQVIA, Nov 2021, LHS graph - Value, RHS Graph - Volume, MAT, Europe, Middle East & Africa, Share of growth not depicted due to too high numbers; NN: Novo Nordisk -Market growth (right axis) NN growth (right axis)

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