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Investor Presentaiton

50 Investor presentation Full year 2022 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 45% Long- Acting 38% Fast- 52% 97 40 Acting 70% Premix 17 33% Human 23 Novo Nordisk 139 Competitors Market growth A Market share 277 6.1% +0.8% 50% Insulin volume: Market share Novo NordiskⓇ 47% 10% 40% 7% 6.2% +1.5% 30% 4% 9.0% +0.2% 20% -1% 1% 10% -3.2% +2.0% 0% Nov 1.1% -1.5% 2019 -NN market share Source: IQVIA, Nov 2022, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk -2% -2% -5% Nov 2022 Market growth (right axis) NN growth (right axis)

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