Investor Presentaiton

BIOND BIOLOGICS INspire Target Product Profile Technology Description Therapeutic binding agents able to block or activate intracellular targets and pathways The agents are chemically linked to a proprietary chemically modified carrier enabling the transport of the agent inside cells • . E Scientific Rationale Biologic agents, e.g. antibodies, cannot enter cells Many cancer and other diseases are caused by abnormal intracellular proteins, protein-protein interactions or pathways which are deemed undruggable due to the requirement of interference by a biologic agent The INspire agents can effectively address these undruggable targets and yield novel therapies MOA/Clinical Pharmacology The ability to target intracellular targets with biologic agents enables to address targets that cannot be addressed with small molecules and exploits their selectivity and high affinity to avoid off-target effects Strategic Context / Differentiation • Novel technology inspired therapeutic agents with unique MOAS • ☑ Indication(s) and patient population The INspire agents can be used to address multiple diseases and conditions The first INspire product will address HPV-E7 cancers where there is still unmet need and very clear patient selection criteria 目 ㅍ Stage Successful in vitro proofs of concept (HPV+ and KRAS cancers) PK and biodistribution successful PoC In vivo proof of concept studies are ongoing Biond Biologics Corporate Presentation | May 2021 | Non-confidential 38

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