EVOLUTION AT MERCK - INVENTING FOR LIFE

EXTENSIVE ONCOLOGY PIPELINE COVERING ALL ASPECTS OF THE TUMOR ENVIRONMENT CD27 CTLA4 CVA21 Other cancer vaccines and viruses PCVs RIG-I STING Antigen-presenting Cell (APC) or Tumor Cell T-Cell priming and trafficking to tumor CD27 PD-1 GITR CTLA-4 Activated T cell Antigen-presenting Cell (APC) or Tumor Cell 2 Immunosuppressive microenvironment Inhibitory ligand on tumor and stroma Immunosuppressive metabolic environment CCR5 CXCR2 GITR IDO/TDO CTLA-4 Suppressive myeloid cells and Treg PD-1 ILT3 Treg (Regulatory T Cells) ILT4 IL10 LAG-3 Naive T cell 3 Direct tumor cell killing (immunogenic) CDK ERK Treg GITR Activated T cell inhibitory signal IDO/TDO PD-1 .Arginase LAG-3 TIGIT IL-10 Myeloid Cell Anergic T cell PD-1 PD-1/LAG-3 bi-specific Pi3K-delta TGFẞ TIGIT CEACAM1 TLR4 MERCK # Dr. Roy Baynes | INVENTING FOR LIFE 58

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