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Investor Presentaiton

Investor Presentation First six months of 2018 Novo Nordisk volume market share is now ~36% of the basal insulin market in the USA Weekly TRx volume market shares* in the USA - glargine U100 Basal volume TRX MS* NN Total Basal TresibaⓇ LevemirⓇ glargine U300 biosimilar glargine U100 70% 60% 50% 40% 30% 20% 10% 0% Apr 2016 39.4% 35.8% 22.7% 12.8% 10.4% 8.2% Jul 2018 Note: The graph does not show NPH, which accounts for the residual market share Source: IQVIA weekly Xponent Plantrak (*excludes Medicaid), 6 Jul 2018 TRX volume: Insulin volume in mega units (MU) associated with total number of prescriptions; VANTAGE FingerTip Formulary bridge, Jul 2018 MS: Market share Medicaid represents ~12% of retail basal market volume Slide 8 TresibaⓇ launch in the USA TresibaⓇ volume market share is now around 13%. TresibaⓇ has gained around 3% market share since the beginning of 2018 TresibaⓇ formulary access is above 80% for Commercial and Medicare Part D combined Main market share driver in first half of 2018 has been the formulary change at CVS part D In mid-April 2018, promotional activities were initiated to promote the updated TresibaⓇ label, including a 40% reduction of severe hypoglycaemic events compared to insulin glargine U100. novo nordisk
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