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Investor Presentaiton

Research Models & Services (RMS) Overview #1 Global RMS Position ā—‰ - - - Global leader in breeding and distribution of research models -40% CRL Largest selection of the most widely used research model strains in the world Expertise in biosecurity supports production of high-quality models, reducing risk to critical research Sustained by the assurance of animal welfare with 4Rs commitments Global footprint with facilities strategically located in close proximity to clients Premier provider of services that support the use of research models in discovery/development of new molecules Genetically Engineered Models & Services (GEMS) Research Animal Diagnostic Services (RADS) Global RMS Market Sector Size: ~$2B ~1 of 2 Small models sold in Western regions is a CRL research model Insourcing Solutions (IS), including CRADL TM operations Cell Solutions provides research, clinical, and CGMP-quality human-derived cellular products used in allogeneic (donor-derived) and autologous (patient- derived) cell therapies Charles River Laboratories (CRL) 3
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