Benevolent Platform Precision Medicine
Prediction strategy geared for identification of fibrotic
regulators driven through oxidative stress
Target identification and hypothesis validation strategies
were aligned to identify targets that could impact:
•
Fibrosis (hepatic stellate cell activation assay)
⚫ Steatosis (hepatocyte lipid accumulation assay)
Models were trained using datasets focussed on:
• NAFLD disease biology
•
Oxidative stress mechanism
1
Define biological
question and assays
2
Transcriptomics data
selection
3
Models run
Normal liver
First hit
Insulin resistance
↓ẞ-oxidation
↑ De novo fatty
acid synthesis
4
Target Triage
NAFLD
NASH
Fibrosis/Cirrhosis
5
Second hit
Hypothesis validation
↑ Oxidative stress
Necroinflammation
and inflammation
Targets A & B
ΑΙ
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