Semaglutide Weight Management and Cardiovascular Risk Reduction
HFPEF compromises -50% of all HF cases, and -80% of HFPEF
patients live with overweight or obesity
Heart failure with preserved ejection fraction
•
Impaired filling capacity
Stiff and thick ventricle
LVEF ≥50%
Approximately 26 million people have HFPEF and BMI>271,2
64m
32m
26m
تھی
Patients with HFPEF are under a great burden³
Higher mortality rate
Higher risk of hospitalisation
Higher burden of debilitating symptoms, physical
limitations and poor quality of life
The key goals of therapy³
Prolong survival
Reduce hospitalisations
Reduce symptoms; improve quality of life and
functional status
HF
HFPEF
Prevalence of HFPEF and BMI>27
1. Groenewegen A et al. Eur J Heart Fail 2020;22:1342-13561; Gurwitz JH et al. Am J Med 2013;126:393-400; 2. Haass M et al. Circulation 2011;4:324-331; Kitzman DW, et al. J Am Coll Cardiol 2016;68:200-203 3. Ponikowski P et al. Eur J Heart Fail 2016;18:891-975
LVEF: Left ventricular ejection fraction; HF: Heart failure; HFPEF: Heart Failure with preserved ejection fractionView entire presentation