EVOLUTION AT MERCK - INVENTING FOR LIFE

OVER 150 DISCOVERY & EARLY DEVELOPMENT PROGRAMS ACROSS BROAD SET OF DISEASE AREAS • Innate Activation / Checkpoint / Costimulatory Immunocytokines • Tumor Intrinsic • Myeloid and Stromal • Metabolism Virus and Vaccines • Other • • • Neuronal Signaling Cell Homeostasis Neuroimmunology Lipid Biology • Redox / Stress . Other 1 CRMO - Cardiovascular, Renal, Metabolic, Other Immuno- Oncology CRMO¹ 15% 35% Neurology 20% ID/Vaccines 30% Heart Failure Vascular Disease Complications of diabetes / obesity Other · HIV % Programs per area Therapeutic-agnostic approach Vaccines Antibacterial / Antifungal Antivirals Other MERCK INVENTING FOR LIFE Dr. Dean Li 77

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