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Investor Presentaiton

Smart Liquid Biopsy: key technology differentiators INVESTOR 20 DAY 23 Single sample workflow for efficiency Genomic mutations + Epigenomic profiles GUARDANT™ Genome wide profiling >20X more detectable alterations1 Highly efficient molecule capture for optimal detection 3X more signal molecules captured² Background depletion for optimal cost 99% depletion for 7X sequencing cost savings² Continuous improvement powered by samples & data bank 500K samples, multiple cycles of 2X performance gains³ 1. In comparison to tissue-informed assays, based on Guardant's internal data, 2. In comparison to off-the-shelf bisulfite workflows, based on Guardant's internal data, 3. In comparison to previous versions of Guardant's workflows, based on Guardant's internal data 31
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