Q4 2021 Results

Company overview Pharmaceuticals Participants Financial performance CRM IHD Oncology Financial review Conclusion Appendix Innovation: Pipeline overview Innovation: Clinical trials Oncology: Solid Tumors Hematology Biosimilars Global Health Abbreviations Neuroscience Ophthalmology Respiratory & Allergy Clinical Trials Update Includes selected ongoing or recently concluded global trials of Novartis development programs/products which are in confirmatory development or marketed (typically Phase 2b or later). For further information on all Novartis clinical trials, please visit: www.novartis.com/clinicaltrials. 66 Investor Relations | Q4 2021 Results 1 NOVARTIS | Reimagining Medicine

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