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Investor Presentaiton

Innovation: R&D pipeline changes since last quarter Phase I +4348413 (GMMA) Gonorrhea +5251738 (TLR8 agonist) HBV +4524184 (integrase inhibitor) HIV +4172239 (DNMTI inhibitor) sickle cell disease +3536867 (bivalent conjugate) Salmonella (Typhoid + Paratyphoid A) +XMT-2056 (STING agonist ADC) cancer (wholly owned by Mersana Therapeutics) 3915393 (TG2 inhibitor) celiac disease* ** Phase II 4406371 (live, attenuated) MMRVns 4106647 (protein-adjuvant) HPV BVL-GSK098 (ethionamide booster) tuberculosis VIR-2482 (neutralizing monoclonal antibody) influenza + Benlysta (anti-BLYS) Systemic sclerosis associated interstitial lung disease 3878858 (bioconjugated, recombinant protein) S. aureus Phase III + tebipenem pivoxil (antibacterial carbapenem) CUTI bepirovirsen (HBV ASO) HBV Registration 4353001 (Sanofi) COVID-19 Rotarix liquid US (live attenuated, PCV free) rotavirus Covifenz (Medicago) COVID-19*** Key + Addition to pipeline Deletion from pipeline due to approval or termination Progressed to new phase GSK * GSK has an exclusive global license option to co-develop and commercialize the candidate **Asset returned to Research, termination for indication only 33 33
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