Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results slide image

Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

We Have Transformed into a Rare Disease Focused Company through Acquisitions 2014 September 2014 Acquisition of Vidara Therapeutics Intl. ACTIMMUNE™ (Interferon gamma-1b) HORIZON RAVICTI (glycerol phenylbutyrate) Oral Liquid May 2015 Acquisition of Hyperion Therapeutics, Inc. 2015 January 2016 Acquisition of Crealta Holdings LLC 2016 KRYSTEXXA! pegloticase 12-HOUR PROCYSBI (cysteamine bitartrate) delayed-release capsules HZN-003 and HZN-007 for uncontrolled gout October 2016 Acquisition of Raptor Pharmaceutical Corp. January 2018 • Acquisition of HZN-003 from MedImmune LLC • Partnered with XL-protein GmbH on HZN-007 (PASylated Uricase) 2016 2017 2018 2019 May 2017 January 2019 Acquisition of River Vision Development Corp. Collaboration with HemoShear Therapeutics LLC TEPEZZA.M teprotumumab-trbw Gout Discovery Collaboration 38
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