Investor Presentation

EXECUTING FOR GROWTH IN 3 LARGE MARKETS TOBACCO VLN® is the Only Combustible Modified Risk Tobacco Product Disruptive Plant Science and Intellectual Property CANNABIS Pharmaceutical CDMO and Best-In-Class Ingredients Platform HOPS Accelerating the Development of Proprietary Specialty Hop Varieties and Valuable Commercial Traits ■ Strong VLN® Chicago pilot results driving expansion in the ~$80 billion U.S. market¹ and +$800 billion global market² ■ 22ND CENTURY GROUP Announced expansion in Illinois, accelerated entry into ~$600 million Colorado market³, with favorable MRTP tax status ▪ Advancing additional U.S. and international markets to accelerate VLNⓇ growth ■ GVB acquisition in May '22 doubled corporate revenue, accelerates path to profitability in the $100 billion hemp/cannabis market4 Prineville world-scale extraction facility >20,000 kg/month Integrating XXII proprietary plant science Expanding white-label customer penetration Advancing hops plant science to deploy alkaloid technologies in a $680 billion global brewing market5 1. Grandview Research; https://www.grandview research.com/industry-analysis/us-tobacco- market#:~:text-The%20U.S.%20tobacco%20market%20size%20was%20est ted%20at%20USD%207 2. Foundation for a Smoke Free World; https://www.smokefreeworld. 3. Smoker Incidence Studies / Industry Data / XXII Internal Research 4. Grandview Research; https://www.grandviewresearch.com/industry-analysis/legal-marijuana-market 5. Grandview Research; https://www.grandviewresearch.com/industry-analysis/beer-market n%20in%202022 20Nicotines OReport%20December%202021.pdf. 3

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