BioNTech Investor Day Presentation Deck

Individualized vaccine manufacturing 1 Individual patient samples (blood and tissue) NORMAL GGGAAACTTTTTCC TUMOR 2 GGGAAACGTTTTCC Mapping of mutations Mutation 1 Vaccine Backbone Kreiter, Vormehr et al, Nature 2015; Kranz, Diken et. al. Nature 2016. 3 Neoantigen prediction Mutation 2 Mutation N Linker Linker messenger RNA Vaccine 4 On-demand tailored RNA manufacturing Linker Mutation N+1 5 L& Individualized immunotherapy mu Vaccine Backbone Target discovery BIONTECH 24

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