Dare Bioscience Investor Presentation Deck
Sildenafil Cream, 3.6% - Thermography Study Results*
Demonstrated time to effect (See Figure 1)
Positive cognitive arousal responses
were noted.
Significantly greater increases in genital
temperature after application of
Sildenafil Cream compared to placebo
cream.
Significantly greater self-reported
arousal responses reported during
Sildenafil Cream visits compared to
placebo cream visits.
Figure 1. Clitoral temperature change during the sexually explicit film
Temperature Change (C)
3
2.5
2
1.5
1
0.5
0
Sildenafil Cream, 3.6%
Sildenafil Cream
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Time (minutes)
Placebo Cream
Placebo Cream
1. Data on file.
* Thermography utilizes sensitive cameras capable of detecting and recording temperature variations over time. Genital temperature changes are a surrogate for genital blood flow.
...... No Cream
Thermography Study Design & Methodology (N=6)¹
Phase 1, single-dose, double-blind, placebo-controlled, 2-way crossover study evaluating the feasibility of using thermography to
assess the pharmacodynamics of Sildenafil Cream, 3.6% in normal healthy women. The study required 3 visits and a follow up
contact: Visit 1 (screening), Visits 2-3 (double-blind dosing) and a phone call (safety follow-up).
Statistically
significant greater
linear slope during
minutes 11-15 of the
sexually explicit
stimuli as compared
to the placebo cream
for the vestibule.
&
darébio
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