Context Therapeutics Investor Presentation Deck

Claudin (CLDN) Proteins ● Tight junctions (TJ) regulate cell barrier and permeability CLDN proteins constitute a structural core of TJ, along with junction adhesion molecule (JAM) and occludin Over 20 CLDN proteins have been characterized Dysregulation of CLDN protein expression and function occurs in multiple diseases, including cancer 14 Context Therapeutics Inc. - Sept. 2022 Tight Junction Structure¹ ZO proteins CLDN6xCD3 Bispecific Antibody Program Actin filament Claudin JAM Occludin 1 Otani, Trends in Cell Biology, 2020

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