Investor Presentation First Nine Months of 2022

113 Investor presentation First nine months of 2022 Insulin market size and volume share of growth and market share in International Operations Insulin market share and market size (DKK billion) Total 51% Long- Acting 38% Fast- acting 59% 16 Premix 79% 9 47% Human 8 Novo Nordisk 30 30 Competitors Market growth A Market share 80% 63 3.6% +1.0% 60% 4.5% +2.2% 40% 4.4% -0.6% 20% 2.9% +2.3% 0% Aug -0.5% -1.1% 2019 Source: IQVIA, Aug 2022, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Insulin volume: Market share Novo NordiskⓇ 15% 12% 50% 9% 6% 1% 3% 0.4% 0% Aug 2022 -NN market share -Market growth (Right Axis) NN growth (Right Axis)

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