Q1'21 Earnings Presentation

Strategy and business Further embedding ESG to build a more responsible bank Environmental: supporting the green transition Helping customers go green Financial advisor on the issuance of 4 Bonds in 2020: 1 Green 2 Sustainable 1 Gender Bond Social: building a more inclusive society Talented & diverse team Top 91 company 15.4% women in to work for leadership positions Bond FEFA 20V Bonds Rotoplas AGUA 17-2X FIRA 20G- 1st Gender bond in Mexico VINTE 20X #1 in Project Finance LT (Dealogic tables) SCIB Mexico SAM-ESG → 1st sustainable equity fund in Mexico Going green ourselves Carbon Neutral in our own operations - 67,845 tons CO2 Voluntary Cancelation Certificate (CER) Financially empowering people 156,542 loans approved in 2020 835,159 people² since 2019 238,244 beneficiaries from financial education programmes in 2020 Supporting society 138,019 people helped since 2019 47,622 scholarships granted since 2019 Governance: doing business the right way A strong culture Simple, Personal, Fair Taking ESG criteria into account when determining remuneration An independent, diverse Board 70% Independent directors³ 40% Women On Board Other programmes: D&I Cultural Transformation Mujer Líder Santander Programme Gender Violence Programme Benefiting almost 8,000 employees (1) Top 10 company to work for Santander (2) (3) 7 out of 11 proprietary members are independent People financially empowered through Santander initiatives Member of Dow Jones Sustainability Indices Powered by the S&P Global CSA ^ SAMI Sustainability Award Industry mover 2020 FTSE4Good EMPRESA A SUSTENTABLE 10

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