Investor Presentaiton

SAR-bisPSMA diagnostic in untreated, confirmed prostate cancer PROPELLER Comparison of 68 Ga PSMA-11 (image left) to Clarity's 64CU SAR-bisPSMA (image right) in the same patient CLARITY 2014 M 68 Ga PSMA-11 (~200MBq) 64Cu SAR-bisPSMA (~200MBq) Max Mean 6.3458 SUVbw Max Mean 18.5497 SUVbw 2.0077 SUVbw 1.2176 SUVbw Max Min 0.1779 SUVbw Mean Diam 2.6334 cm Max Sl 561 Peak 3.1876 SUVbw Min Diam Max Sl 181 Peak 16.5398 SUVbw 3.5148 SUVbw 0.6203 SUVbw 2.6334 cm Min 0.1464 SUVbw Diam 2.6334 cm Max SL 179 Peak 6.8438 SUVbw 7.283 SUVbw Max 6.4652 SUVbw Mean 2.2353 SUVbw Min 0.7628 SUVbw Diam 2.6334 cm Max Sl 569 Peak 3.6116 SUVbw 68 Ga PSMA-11 (~200MBq, left) vs. 64CU SAR-bisPSMA (~200MBq, right) in the same patient; time between serial imaging was 8 days. Standardised Uptake Value (SUVmax)* of the lesions were 6.5 and 6.3 for 68Ga PSMA-11 and 16.5 and 18.5 for 64Cu SAR-bisPSMA. *SUV is a measurement of product uptake in tissue normalised to a distribution volume 16

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