Phesgo and Tecentriq Performance and Approvals

Exchange rate impact on sales growth Negative impact driven by the JPY, EUR and CNY CER sales growth Q1 2023 VS. Q1 2022 -3.1% -0.7p +0.1p -0.9p -0.4p -1.2p -0.2p -0.4p -6.8% CER EUR APAC USD LATAM JPY Other Other Europe CHF CER = Constant Exchange Rates (avg full year 2022) Roche CHF sales growth Q1 2023 VS. Q1 2022 46 46

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