Investor Presentaiton

Syphilis serology Timing of serologic responses in syphilis infection % of patients who test positive 100 80 60 40 20 2468 10 12 Weeks FTA-Abs TPHA IgMa Untreated VDRL/RPR 2 10 Years Time post infection Secondary Time of infection Primary lesion lesion Clinical stages of syphilis Primary I Secondary Treated Latent (Asymptomatic) I Tertiary 20 Higher numbers correspond to higher level of antibodies in patient's serum ■ Number determined by progressive dilution of serum until it becomes. non-reactive ■ A two-fold change such as 1:32 to 1:16 is generally considered within margin of test error Sustained four-fold change such as 1:64 to 1:16 is considered significant Source: Henao-Martínez, A. F., & Johnson, S. C. (2014). Diagnostic tests for syphilis: New tests and new algorithms. Neurology. Clinical practice, 4(2), 114–122. https://doi.org/10.1212/01.CPJ.0000435752.17621.48 Saskatchewan + Health Authority

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