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Investor Presentaiton

Advancing Guardant360 TissueNext with Al-powered digital pathology INVESTOR 20 DAY 23 GUARDANT 360 TissueNext GUARDANT GALAXY PD-L1 Only tissue CGP panel with an Al-powered scoring algorithm that improves PD-L1 detection by >20% in NSCLC1 Now validated for multiple cancers² Covered by Medicare for all advanced solid tumors³ GUARDANT™ Al = Artificial Intelligence. *Compared to manual pathologist interpretation in the most challenging cases in NSCLC. Including breast, colorectal, gastric, hepatobiliary, lung, pancreatic, prostate, and urothelial cancers. 1. https://www.ejcancer.com/article/S0959-8049(22)00215-5/fulltext. 2. https://www.annalsofoncology.org/article/S0923-7534(21)01146-7/fulltext Important Note: Guardant360 TissueNext and Guardant Galaxy PD-L1 tests were developed, and their performance characteristics determined, by Lunit. These tests have not been cleared or approved by the US FDA. 3. Coverage limited to LFS for PDL-1 test. 53 53
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