Investor Presentation Full Year 2021

113 Investor presentation Full year 2021 Medicare Uninsured 333 US health insurance is dominated by few large commercial payers with slow expansion of public insurance coverage The US population by health insurance status has been stable in ■Managed Care Medicaid/CHIP recent years Public exchanges 326 Covered lives by PBM in 2021 All other PBMS 14% Cigna CVS Caremark 100% 3% 29% 9% Humana 8% 3% 80% 23% 22% Prime 9% 60% 18% 17% 40% 45% 46% 20% 20% 22% OptumRx 0% 1 2017 2021 Express Scripts NAO 12017 data reflect historical data through Oct 2017 2 Managed care population is slightly underestimated as only population under the age 65 is captured to avoid double counting with those eligible for Medicare. Source: Centres for Medicare and Medicaid services, office of the actuary, National Health expenditures Projections PBM: Pharmacy Benefit Manager Note: Covers all main channels (Managed Care, Medicare Part D, and Medicaid); market share based on claim adjudication coverage, i.e. not on formulary/rebate decision power Sources: Cleveland Research

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