Q4 2021 Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix Financial performance Innovation: Pipeline overview Innovation: Clinical trials CRM IHD Neuroscience Ophthalmology Respiratory & Allergy Oncology: Solid Tumors Hematology Biosimilars Global Health Abbreviations Cosentyx® - IL-17A inhibitor Study Indication Phase Patients NCT03031782 (CAIN457F2304) JPSA & ERA Phase 3 80 Primary Outcome Measures Time to 33 flares Arms Intervention Secukinumab (pre-filled syringe) 75 mg Placebo Juvenile idiopathic arthritis subtypes of psoriatic and enthesitis-related arthritis Target Patients Read-out Milestone(s) H1-2021 Publication H2-2021 NCT03259074 SURPASS (CAIN457K2340) JPSA & ERA Phase 3 837 No radiographic structural progression as measured by modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) Secukinumab 150/300 mg Adalimumab biosimilar 40 mg Patients with active ankylosing spondylitis 2022 Study design manuscript published. Baraliakos et al. Clinical Drug Investigation (2020) 40:269-278. 79 Investor Relations | Q4 2021 Results NOVARTIS | Reimagining Medicine

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