Investor Presentaiton

Most overdose deaths now involve multiple substances. 50% 40% Percent of unintentional medication, drug and alcohol poisoning deaths involving multiple substances 30% 70% 2 substances 3 substances 4+ substances 60% 22% 23% 21% 22% 20% 20% 17% 18% 17% 17% 10% 0% 1999 2000 2001 2002 2003 2004 2005 24% 22% 23% 24% 27% 2006 2007 2008 2009 2010 2011 2012 2013 25% 2014 2015 38% 59% 53% 48% 2016 2017

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