Novo Nordisk Annual Report 2021

Contents Introducing Novo Nordisk Strategic Aspirations Key risks Management Consolidated statements Additional information. Novo Nordisk Annual Report 2021 19 Diversity and inclusion challenges and opportunities vary depending on the local context and the societies that we serve. To ensure we consider the local context, drive impact at all levels and hold our leaders accountable for driving progress, all our senior leaders across the company have been asked to define local diversity and inclusion aspirations and associated action plans. We expect all our leaders to embrace their role as inclusive leaders by being committed to building diverse teams of complementary strengths, valuing diverse perspectives and creating a psychologically safe space in which all employees feel free to speak up. Progress of diversity and inclusion has been anchored in both short-term and long-term incentive programmes and we follow up and track progress on a regular basis. Please refer to note 8.5 on Gender diversity on page 89 for further information. Please refer to the Corporate Governance Report available at novonordisk.com for further information on D&I targets regarding the Board of Directors. Sustainable tax approach Our overall guiding principle within taxation is to have a 'sustainable tax approach', emphasising our business anchored approach to managing the impact of taxes while remaining true to the Novo Nordisk values of operating our business in a responsible and transparent manner. This means that we pay tax where value is generated and always respect international and domestic tax rules. As a global business, we conduct cross-border trading, which is subject to transfer pricing regulations. We apply a 'Principal Corporate income taxes by region - three year average Share of category Region Intellectual property rights Production² Sales³ International Operations - Denmark - EMEA (excluding Denmark) - China - Rest of World North America Operations - Of which the US Total 2021 Corporate income taxes (DKK billion) 9.3 Human rights' risk management We are committed to respecting human rights as per the UN Guiding Principles on Business and Human Rights (please refer to the Governance section on page 20 and novonordisk.com). We continue to integrate human rights risks into our risk management process, across our operations and business relationships. 8.0 0.6 0.4 0.3 1.3 1.2 10.6 1. Intellectual property rights based on sales from where intellectual property rights are located 2. Production based on production employees in the region 3. Sales based on the location of the customer structure' in line with OECD principles, meaning all legal entities perform their functions under contract on behalf of the principals and are allocated an activity-based profit according to a benchmarked profit margin. The tax outcome of this operational model is reflected in the overview above, which shows our corporate income taxes by region. To ensure alignment between taxing authorities about the allocation of profit between our entities, we have Advance Pricing Agreements in place for geographies representing around 65% of our revenue worldwide. Our tax policy has been approved by the Board of Directors. Read more about this topic at novonordisk.com. In addition to corporate income taxes, we also pay other taxes. Please refer to note 8.6 on Total tax contribution on page 90 for further information. Sierra Clark lives with Glanzmann Thrombasthenia in Canada

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