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Investor Presentaiton

The prevalence of anaemia increases as CKD progresses; it is associated with an increased risk of hospitalisation, cardiovascular complications and death gsk North America 30 million CKD prevalence Europe 25 million CKD prevalence 16 million Stages 3-5 19 million Treating patients with anaemia due to CKD Stages 3-5 Diagnosed Average treatment Stage of CKD Kidney function % patients duration (m) (years) Primary care physician and Nephrologist Stage 3a 45-59 4.4 7.9 Stage 3b 30-44 5.6 5.0 Stage 4 15-29 1.3 4.2 Asia Nephrologist Stage 5 <15% 0.5 0.8 367 million CKD prevalence 123 million Stages 3-5 Source: 1. NHANES 2016 data accessed via Centers for Disease Control and Prevention. CKD Surveillance System-United States; website: http://www.cdc.gov/ckd; 2. 2018 USRDS Annual data report-Volume 2: ESRD in the US 3. Lancet: Global, regional and national burden of chronic kidney disease, 1990-2017; 4. The prevalence of Chronic Kidney Disease in Asia, Liyanage T, Toyama T, ISN WCN 2020. 5 Spherix RealWorld Dynamix ND Patient Audit Neph and PCP-2019, 6: GSK internal materials, 7. Dowling TC. Am J Health Syst Pharm 2007;64(13 Suppl 8):S3-7., Schmidt RJ, Dalton CL. Osteopath Med Prim Care 2007;1:14. 21
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