Investor Presentation Q1 2022

9 Investor presentation First three months of 2022 Obesity care sales grew by 107% in the first quarter of 2022 Global market growth and market share within Obesity care Reported Obesity care sales split DKK billion 42%¹ DKK billion 3%1 55%¹ 107% 90% 3 82% 2,4 1,8 1,2 0,6 60% 3.4 2.4 2.5 1,4 2.0 0,5 0,8 0.1 1.6 30% 2,0 1,9 1,9 1,7 1,6 0 0% 2019 2020 2021 2022 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2022 NAO IO -Market share (RHS) SaxendaⓇ WegovyⓇ Growth at CER 1 Annual growth at CER. NAO: North America operations, IO: International operations, RHS: Right hand side axis, Note: Sales growth at constant exchange rates; Novo NordiskⓇ

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