Kymera Investor Presentation Deck
Mean % Change (+/- S.E. of Mean)
O
-10
-20
-30
-40
-50
-60
-70
-80
O
-26.9
KYMERA
Mean % Change in Average
Pain Over Past Week
7
-23.4
-38.7
14
-40.1
-56.1
HS: Significant Reductions in Pain/Pruritus
% of Patients with ≥30% and ≥1
Unit Reduction in Worst Pain
Over the Past Week
-48.6
-64.6
21
Day
-53.8
-65.7
28
All HS Patients (N=12)*
Moderate to Severe (N=10)
-59.7
F
-60.1
35
-60.4
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42
% of Pain Responders (80% CI)
100
90
80
70
50
40
30
20
10
O
0
20
7
17
50
14
42
70
58
21
Day
60
50
28
All HS Patients (N=12)
Moderate to Severe (N=10)
60 60
50
35
50
42
Mean % Change (+/- S.E. of Mean)
-10
-20
-30
-40
-50
-60
-70
-80
-90
-100
0
Mean % Change in Worst
Pruritus Over Past Week
-29.1
7
-17
-41.7
-26.1
-41.9
14
-24
*One patient is censored for Day 35 and Day 42 since the patient started on ustekinumab, steroids and abx on Day 34.
-67.8
21
Day
All HS Patients (N=12)*
Moderate to Severe (N=10)
-48.6
28
-62.3
-53.6
35
-61.6
-68.4
42
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