BioNTech Investor Day Presentation Deck

Computerized prediction of mutations 3 #001 #002 #003 #... #267 Individual patient samples (blood and tissue) Gene 1 KIF21B Computer predicted mutation list Key PIK3CA R115L IMPA2 R202P KRAS G12D Kreiter et. al. Nature 2015 Mut NORMAL GGGAAACTTTTTCC TUMOR 2 GGGAAACGTTTTCC Mapping of mutations Chrom Score 3 18 12 P188S 1 3,45 0,2 0,3 0.45 Neoantigen prediction 4 On-demand tailored RNA manufacturing 8 2 5 MMMM H& Individualized immunotherapy Target discovery Verification by Expert Review BIONTECH 23

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