Bionomics IPO Presentation Deck

Pan Nav Inhibitors: Potential Non-Addictive, Reduced Side-Effect Chronic Pain Therapies Disease-Related Genetics BNO Pan Nav inhibitors Small molecules with functional selectivity for voltage gated sodium channels: Nav1.7, Nav 1.8 and potentially Nav1.9 Bionomics Gain & Loss-of-function mutations in Nav1.7, 1.8 and 1.9 1000+ COMPOUNDS SYNTHESIZED 2 SERIES PATENTED LEAD COMPOUND BL-017881 BACK-UP COMPOUNDS 3 Patents Published Associated with human pain syndromes where extreme pain or no pain is experienced Lead Candidate Identified BL-017881 OBSERVED TO REVERSE PAIN IN THE FORMALIN PAW MODEL IN MICE 28

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