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Reimagining Medicine

Company overview Innovation: Pipeline overview Financial review Financial performance Conclusions Appendix Innovation: Clinical trials H1 growth driven by strong performance from EntrestoⓇ KesimptaⓇ, PluvictoⓇ and KisqaliⓇ H1 sales Entresto Sales USD million Growth vs. PY USD million 2,915 sacubitri/valsartan Kesimpta 873 (ofatumumab) PLUVICTO™ 451 KISQALI 908 361 ribociclib SCEMBLIX® 182 126 (asciminib) LEQVIO® 142 106 PROMACTA® 1,130 105 (eltrombopag) Tafinlar. Mekinist. 954 99 299 Adanie LUTATHERA 88 PIQRAY 246 (alpelisib) tablets 88 ILARIS (canakinumab) rolex 644 84 Growth vs. PY CC 697 35% 439 439 References Abbreviations GROWTH 103% nm Strong growth (+69% cc); 73% expected to continue 228% 293% 13% 15% 43% 57% 18% Constant currencies (cc) is a non-IFRS measure; explanation of non-IFRS measures can be found on page 48 of Condensed Interim Financial Report. Unless otherwise noted, all growth rates refer to same period in PY. nm not meaningful. 38 Investor Relations | Q2 2023 Results U NOVARTIS | Reimagining Medicine
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