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Investor Presentaiton

Novo Nordisk Annual Report 2023 PERFORMANCE HIGHLIGHTS Introducing Novo Nordisk Strategic Aspirations Risks Management Consolidated statements Additional information 8 Our strategy execution progress Purpose and sustainability Strategic Aspirations 2025 Progress towards zero environmental impact Being respected for adding value to society Further raise the innovation-bar for diabetes treatment Innovation and therapeutic focus Being recognised as a sustainable employer ☑ Commercial execution Financials Develop a leading portfolio of superior treatment solutions for obesity Strengthen and progress the Rare Disease pipeline Establish presence in Cardiovascular & Emerging Therapy Areas focusing on CVD, MASH and CKD Strengthen diabetes leadership - aim at global value market share of more than 1/3 More than DKK 25 billion in Obesity sales by 2025 Secure a sustained growth outlook for Rare Disease Deliver solid sales and operating profit growth Drive operational efficiencies across the value chain to enable investments in future growth assets Deliver free cash flow to enable attractive capital allocation to shareholders Progress Carbon emissions from operations and transportation decreased by 34% compared to 2019 (decreased by 8% compared to 2022) Medical treatment provided to 40.5 million people living with diabetes Reached more than 52,000 children in Changing Diabetes in Children programme Human insulin with more flexible storage without refrigeration now approved in 29 countries Partnership with Aspen to produce human insulin for people living with diabetes in Africa Share of women in senior leadership positions has increased to 41% from 39% in 2022 Regulatory submission of once-weekly insulin icodec in the EU, the US and China Successful completion of phase 3 trial with higher doses of oral semaglutide Initiation of phase 3a trial with CagriSema in type 2 diabetes FLOW kidney outcomes trial stopped based on interim analysis due to efficacy Successful completion of phase 3 trial with IcoSema • Successful completion of phase 3 trial with 50 mg of oral semaglutide Successful completion of SELECT cardiovascular outcomes trial • Successful completion of STEP HFPEF phase 3 trials Acquisition of Inversago Pharma and phase 2 trial initiated with INV-202 and phase 1 trial initiated with INV-347 • Successful completion of phase 1 trial with oral amycretin • Somapacitan approved in the US, EU and Japan for the treatment of growth hormone deficiency in children Phase 1 trials initiated with cell therapy treatment in heart failure and Parkinson's disease Acquisition of ocedurenone for the treatment of hypertension Phase 1 trial initiated with ANGPTL3i mAb Phase 1 trial initiated with VAP-1i in MASH Diabetes value market share increased by 1.9 percentage points to 33.8% (MAT) Obesity care sales increased by 154% (CER) to DKK 41.6 billion Rare disease sales decreased by 15% (CER) to DKK 17.2 billion Sales growth of 36% (CER) Operating profit growth of 44% (CER) Operational leverage reflecting sales growth Free cash flow of DKK 68.3 billion. DKK 61.7 billion returned to shareholders
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