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Investor Presentaiton

Multiple Strategies to Strengthen Portfolio and Enhance Value for Our Clients and Shareholders | | || | _ Disciplined M&A Strategic Partnerships Venture Capital Relationships M&A remains top, long-term priority for disciplined capital deployment and enhances growth strategy Invested >$4.5B in >25 acquisitions since 2012 Focused on enhancing breadth of scientific capabilities, expanding global scale, and maintaining leadership in advanced and emerging therapies Partnerships and licensing arrangements add innovative capabilities and cutting-edge technologies with limited upfront risk -20 active partnerships currently with >$100M invested to date(1) • Highlights include: Distributed Bio (acquired) - antibody discovery SAMDI Tech (acquired) - label-free high- throughput screening (HTS) Cypre 3D tumor modeling Wheeler Bio - Antibody manufacturing Vernal Bio - mRNA manufacturing/LNP design Innovative strategy to establish CRL as a preferred partner to a large group of emerging, VC-backed biotech companies and create value ~10% of annual revenue comes from VC-backed companies (2) Slightly below 30% average annual return on our VC relationships (investments and revenue)(3) (1) Charles River Laboratories (CRL) (2) (3) Amount invested in strategic partnerships excludes purchase price to acquire Distributed Bio. VC revenue includes VC firms with which we have invested, those with which we have a strategic relationship, and other revenue from VC portfolio companies with which we have no formal relationship. Return calculation as of FY 2022 includes VC investment gains and operating cash flow from revenue generated from VC funds in which we have invested (both net of tax). It does not include revenue generated from VC funds in which we have not invested. 20
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