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Reimagining Medicine

Company overview Financial review Conclusions Appendix References CosentyxⓇ sales stabilized; expecting growth in H2 Sales evolution USD m, % cc Ex-US US +1% 1,275 1,272 539 622 736 650 Q2 2022 Q2 2023 GROWTH Cosentyx® Q2 performance US sales (-12% cc): Volume growth offset by revenue deductions (incl. PY base impact) Ex-US sales (+18% cc): Strong growth in core indications China: Outperforming market with double-digit growth post-COVID Expect growth in H2 EU: HS approved in Q2 US: HS and Rheum IV approvals expected H2 US: 300mg autoinjector approved LCM program 3 Ph3 studies ongoing: Giant Cell Arteritis, Polymyalgia Rheumatica, Rotator Cuff Tendinopathy; termination of lupus nephritis HS-hidradenitis suppurativa. IV - intravenous. Constant currencies (cc), core results are non-IFRS measures; explanation can be found on page 48 of Condensed Interim Financial Report. 7 Investor Relations | Q2 2023 Results ✓ NOVARTIS | Reimagining Medicine
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