Investor Presentation Full Year 2017
Investor Presentation
Full year 2017
Diabetes - the inability to manage blood sugar levels
appropriately
Slide 38
Facts about diabetes
Diabetes is a chronic disease that occurs either when the
pancreas does not produce enough insulin or when the body
cannot effectively use the insulin produced by the pancreas
Primary classifications:
Type 1 diabetes: Complete insulin deficiency due to
destruction of beta-cells in the pancreas
Type 2 diabetes: Characterised by some degree of insulin
resistance and insulin deficiency
Insulin:
Facilitates uptake of blood sugar into cells
The aim of insulin therapy is to recreate normal
blood insulin profile
meal-related peaks (prandial)
70T
Short-lived, rapidly generated
60-
긑 50-
Insulin (U/mL)
40-
20-
Sustained
Insulin profile (basal)
•
10-
•
Inhibits glucose release from the liver
0-
6:00
10:00
14:00
18:00
22:00
2:00
6:00
Fat cell
Liver
Pancreas
Muscle
1
Time of day
Breakfast
Lunch
Dinner
changing
diabetes®
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